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Guidance
FastML
M1CR0B1AL1Z3R
Selecton
ConSurf
The Selecton Server
Server for the Identification of Site-Specific
Positive Selection & Purifying Selection
Nucleic Acids Research. 35: W506-W511 (2007)
[pdf]
[abs]
.
Bioinformatics. 21(9): 2101-2103 (2005).
[pdf]
[abs]
DNA coding-sequences
Enter your DNA file (Fasta format only)*
Choose alignment method:
MAFFT-L-INS-i
PRANK
MUSCLE
CLUSTALW
OR
Enter your codon-aligned file (Fasta format only)**
Query sequence name ***
Job title (Optional)
*Either enter unaligned DNA coding sequences in
Fasta
format
**Or enter DNA sequences which are codon aligned, in
Fasta
format
.
***Please enter a reference sequence name,
as it appears in your DNA text file.
The results of the analysis will be displayed on this sequence.
Please enter your email address
Your email address will be used to update you the moment the results are ready.
Advanced options
Protein Structure
Enter the PDB ID:
OR
Enter your own PDB file
Chain Identifier (for none, enter"none")
Tree phylogeny
Enter your tree file in
Newick format
Optimize branch lengths
Genetic Code:
Nuclear Standard
Nuclear Blepharisma
Nuclear Ciliate
Nuclear Euplotid
Mitochondria Vertebrate
Mitochondria Invertebrate
Mitochondria Yeast
Mitochondria Ascidian
Mitochondria Echinoderm
Mitochondria Flatworm
Mitochondria Protozoan
Evolutionary Model
Positive selection enabled (M8, beta + w >= 1)
Null model: no positive selection(M8a, beta + w = 1)
Null model: no positive selection(M7, beta)
Positive selection enabled(M5, gamma)
Mechanistic Empirical Combination Model (MEC)
Number of categories for the distribution:
Empirical amino-acid matrix (for MEC model only):
JTT (default)
WAG
mtREV24 (for mitochondrial proteins)
cpREV45 (for chloroplasts proteins)
Precision level:
Intermediate precision
Low precision- faster run
High precision- slower run